Hospitals

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The population of the ageing of Canada presents a défiformidable forthe pharmaceutical industry and doctors. Tandisque the old people arethe largest consumers desdrogues, he remains much to be informed aboutthe way in which the corpset the drugs of ageing act one on the other.

"the old people are a special population which répondentdifféremmentwith drugs that younger adults," said Dr.Patrick Colin, clinicalvice-president of research at Axcan Pharmainc.. It was presentedduring the 2nd annual meeting del' use of drug in the geriatricpopulation, accomodated by Baycrest Centre for the care geriatric etl'association of the pharmacists of Ontario September 19.

These differences can result from pharmacodynamics andlapharmacocinetic changed, as well as the conditions whichsontcommunes in the old man, like the function renal, hepaticoucardiaque reduced. The concomitant disease, the with-top-drug, orlow conformity are also factors potentiels.Entre the ages of 40 and of80, the average adult loses approximately the moitiéde their functionof kidney.

"there the pressure increases on the pharmaceutical industry ofrecueillirplus of data on the effects of drugs on personnesâgées,"said Dr. Colin, who gave the opening speech to uneassistance of morethan 200 professionals of health-care of the "vieuxpatients must beincluded in the clinical development denouvelles drugs, of newindications or nouvellesformulations of drug of proportioning whenpopulation of patient target inclutdes more than 65."

One expects that the 65-and-older demographic double presquedans thesize by the year 2025. Dr. Colin informed that without dedonnéesobviousness-based collected tests of drug on cegroupe target growing,there will be "increased errors of prescriptionet unfavourablereactions in the future". Dr. Colin pointed out desmédecins in theassistances that the adjustments of therapy sont"essentiels" in theold people. He is not seulementimportant to prescribe the correctamount (the bottom of beginning and allerlent is the best approach),but regularly supervise lathérapie of drug in a patient in order tomake the ajustementsnécessaires. It is also essential to obtain ahistoirecomplète of drug, to consider interactions withautresdrogues, and to look at solutions of replacement of not-drugsiapproprié.

"if you do not consider the pharmacokinetic one and lapharmacodynamyof each drug which you prescribe with a patient, then you are a takerof risk," said Dr. Walter Himmel, unmédecin of help at the generalhospital of the north of York etgénéral of Toronto in the east. Itwas presented on the matter desinteractions of drug in the old people- the perspectived' a doctor of help.

Many unfavourable interactions of drug are foreseeable, ontdit Dr.Himmel. It recommended that all the doctors deprescription carry withthem a wallet on interactionsde drug. The pilots of palm become a toolindispensableaussi well. It moved to www.drug-interactions.comcommeexcellent site with "references and the liensfantastiques ones".